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Oral steroids have been found effective in the treatment of inflammatory reactions associated with allergic states, rheumatic and autoimmune diseases, and respiratory disorders, and have contributed to the development of treatments for chronic asthma. They have been associated with improvements in gastrointestinal diseases of the esophagus and pancreas, which may contribute to improvement of the systemic condition of this condition. However, their use in treating diseases as diverse as asthma, irritable bowel syndrome and chronic fatigue syndrome, or to improve blood pressure of patients who may have elevated blood pressure, such as in patients suffering from coronary artery dissection has not been proven and there is no convincing evidence that oral steroids increase the risk for cardiac events or cardiovascular disease. In contrast, testosterone therapy (treatment of hypogonadism) has been proved in several trials to be effective for the treatment of various diseases, including cancer, and to be associated with a reduced risk of cancer recurrence, including glaucoma, prostate and breast cancer, and osteoporosis.Oral steroids have also been used for preventing osteoporosis in premenopausal women. However, when used for the prevention and treatment of osteoporosis in women of advanced advanced age, in men, as the result of a bone disease, it was not considered to be an effective treatment, despite the fact that the bone disease may be the only factor responsible for causing the decline in the bone mass of elderly women.In a study carried out in 1998 in Japan by Shimoji, Takakuni and Takamura (1), the use of oral testosterone in a group of men with a history of osteoporosis was compared with that in a control group (men without osteoporosis). The group given oral steroids for 2 year showed a significant reduction in total body mass (TBM) compared with that in the control group (Table 1).TABLE 1. Premenopausal men aged 40–55 yr Age (y) Mean SD (standard error) TBM, kg, n Pre-treatment (n = 41) vs Post-treatment (n = 43) Age (y) Mean SD (standard error) TBM, kg, n Pre-treatment (n = 41) vs Post-treatment (n = 43) Sex All 41 ± 11.25 44.7 ± 11.0 41.4 ± 12.9 Male 19 ± 9.0 37.5 ± 5.8 45.0 ± 9.9 Female 46 ± 11.1 44.9 ± 12.2 41.0 ± 11.1 Age-matched 44.8 ± 11.3 40.2 ± 10.5Similar articles: